Gulsevin Lab @ Butler University

Publications

Dr. Gulsevin’s Publications

  1. Ezell, K. M., Tinker, R. J., Furuta, Y., Gulsevin, A., Bastarache, L., Hamid, R., Cogan, J. D., Rives, L., Neumann, S., Corner, B., Kozuria, M., & Phillips, J. A. (2024). Undiagnosed Disease Network collaborative approach in diagnosing rare disease in a patient with a mosaic CACNA1D variant. American Journal of Medical Genetics Part A, e63597.
  2. Arias, H. R., Rudin, D., Hines, D. J., Contreras, A., Gulsevin, A., Manetti, D., Anouar, Y., de Deurwaerdere, P., Meiler, J., Romanelli, M. N., Liechti, M. E., & Chagraoui, A. (2024). The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation. European Journal of Pharmacology, 966, 176329.
  3. Furuta, Y., Tinker, R. J., Gulsevin, A., Neumann, S. M., Hamid, R., Cogan, J. D., Rives, L., Liu, Q., Chen, H.-C., Joos, K. M., Phillips III, J. A., & Undiagnosed Disease Network (2023). Probable digenic inheritance of Diamond–Blackfan anemia. American Journal of Medical Genetics Part A, 1-6.
  4. Papke, R. L., Quadri, M., & Gulsevin, A. (2023). Silent agonists for α7 nicotinic acetylcholine receptors. Pharmacological Research, 190, 106736.
  5. Han, B., Gulsevin, A., Connolly, S., Wang, T., Meyer, B., Porta, J., Tiwari, A., Deng, A., Chang, L., Peskova, Y., Mchaoraub, H., Karakas, E., Ohi, M. D., Meiler, J., Kenworthy, A. K. (2023). Structural analysis of the P132L disease mutation in caveolin-1 reveals its role in assembly of oligomeric complexes. Journal of Biological Chemistry, 299(4),  104574.
  6. McDonald, E. F., Jones, T., Plate, L., Meiler, J., Gulsevin, A. (2023). Benchmarking AlphaFold2 on peptide structure prediction. Structure, 31(1), 111-119.e2.
  7. Han, B., Wilson, L. F. L., Gulsevin, A., Meiler, J., Karakas, E., & Kenworthy, A. K. (2022). Design principles of caveolins across metazoa and beyond. bioRxiv (in submission)
  8. Gulsevin, A.*, Han, B.*, Porta, J. C., Mchaourab, H. S., Meiler, J., Kenworthy, A. K. (2022). Template-free prediction of a new monotopic membrane protein fold and assembly by Alphafold2. Biophysical Journal, 122, 1-12.
  9. Gulsevin, A.*, Porta, J. *, Han, B.*, Chung, J., Peskova, Y., Connolly, S., Mchaourab, H., Meiler, J., Karakas, E., Kenworthy, A., Ohi, M.D. (2022) Molecular architecture of the human caveolin-1 complex. Science Advances 8, eabn7232
  10. Gulsevin, A., Glazer, A.M., Shields, T., Kroncke, B.M., Roden, D.M., Meiler, J. (2022) Veratridine Can Bind to a Site at the Mouth of the Channel Pore at Human Cardiac Sodium Channel NaV1.5. IJMS, 23, 1–13.
  11. Schoeder, C.T., Schmitz, S., Adolf-bryfogle, J., Sevy, A.M., Finn, J.A., Sauer, M.F., Bozhanova, N.G., Mueller, B.K., Sangha, A.K., Bonet, J., … Gulsevin, A., …et al. (2021) Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design. Biochemistry, 11, 825-846
  12. Gulsevin, A., Papke, R.L., Stokes, C., Tran, H.N.T., Jin, A.H., Vetter, I., Meiler, J. (2021) The allosteric activation of α7 nAChR by α-conotoxin MrIc is modified by mutations at the vestibular site. Toxins, 13(8):555
  13. Gulsevin, A. and Meiler, J. (2021) Prediction of amphipathic helix—membrane interactions with Rosetta. PLOS Comput Biol. 2021;17: e1008818
  14. Gulsevin, A. and Meiler, J. (2020) An Investigation of Three-Finger Toxin — nAChR Interactions through Rosetta Protein Docking. Toxins, 12, 598
  15. Gulsevin, A., Meiler, J., Horenstein N. A. (2020) A Computational Analysis of the Factors Governing the Dynamics of α7 nAChR and Its Homologs. Biophysical Journal. 2020;119: 1656–1669
  16. Gulsevin, A. (2020), Nicotinic receptor pharmacology in silico: Insights and challenges. Neuropharmacology, 177
  17. Gulsevin, A., Papke, R. L., Horenstein, N. A. (2020) In silico modeling of the α7 nicotinic acetylcholine receptor: new pharmacological challenges associated with multiple modes of signaling. Mini Reviews in Medicinal Chemistry, 20: 1
  18. Gulsevin, A., Papke, R.L., Stokes, C., Garai, S., Thakur, G.A., Quadri, M., Horenstein, N.A.  (2019), Allosteric agonism of α7 nicotinic acetylcholine receptors: Receptor modulation outside the orthosteric site. Molecular Pharmacology, 95(6):606–14.
  19. Quadri, M., Garai, S., Thakur, G. A., Stokes, C., Gulsevin, A., Horenstein, N. A., and Papke, R. L. (2019) Macroscopic and Microscopic Activation of α7 Nicotinic Acetylcholine Receptors by the Structurally Unrelated Allosteric Agonist-Positive Allosteric Modulators (ago-PAMs) B-973B and GAT107. Molecular Pharmacology, 95, 43 LP-61
  20. Quadri, M., Stokes, C., Gulsevin, A., Felts, A. C. J., Abboud, K. A., Papke, R. L., Horenstein, N. A. (2017). Sulfonium as a Surrogate for Ammonium: A New α7 Nicotinic Acetylcholine Receptor Partial Agonist with Desensitizing Activity. Journal of Medicinal Chemistry, 60(18), 7928–7934.

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